✔ 100% Authentic Product
Letrozole is a potent, nonsteroidal aromatase inhibitor that reduces estrogen biosynthesis by competitively inhibiting the aromatase enzyme. This deprives estrogen-dependent breast cancer cells of their growth stimulus.
- In Postmenopausal Women: Estrogens are synthesized by aromatase converting adrenal androgens (androstenedione, testosterone) to estrone (E1) and estradiol (E2). Letrozole effectively suppresses estrogen levels without affecting androgen levels.
- Suppression Rates: Single doses (0.1–2.5 mg) suppress serum estrone and estradiol by 75–78%, achieving maximum suppression within 48–78 hours.
Pharmacokinetics:
- Absorption: Rapid, complete absorption (bioavailability ~99.9%). Food delays absorption slightly without affecting clinical relevance.
- Protein Binding: ~60% (primarily to albumin).
- Metabolism: Converted to an inactive carbinol metabolite primarily by CYP3A4 and CYP2A6.
- Half-Life: ~2 days.
- Steady State: Achieved within 2–6 weeks of daily 2.5 mg administration.
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cashback offer (Optional):
🔹 Foreign manufacturer products are not applicable for Cashback offer
Cash on Delivery - All over Bangladesh
Urgent Delivery - 2 Hours Dhaka City
ফ্রি ডেলিভারি! - ১৪৯৯ টাকা+ অর্ডারে ঢাকা
শহরে ।- ফ্রি ডেলিভারি! - ২৯৯৯ টাকা+ অর্ডারে ঢাকার
বাহিরে ।
✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects of Letrozol 2.5
Common:
- Hot flashes, hypercholesterolemia, fatigue, sweating, arthralgia, rash, headache, dizziness, malaise.
- Gastrointestinal disturbances: nausea, vomiting, constipation, diarrhea, abdominal pain.
- Musculoskeletal issues: osteoporosis, joint pain/stiffness, fractures.
- Edema, depression, weight gain, hypertension, vaginal bleeding.
Rare:
- Anxiety, insomnia, memory issues, somnolence, blurred vision, skin irritation, carpal tunnel syndrome, urinary tract infections, and increased liver enzymes.
✔️ Dosage & Administration of Letrozol 2.5
Adults and Elderly:
- Standard Dose: 2.5 mg once daily.
- Adjuvant/Extended Therapy: Continue for 5 years or until tumor relapse.
- Metastatic Disease: Continue until tumor progression.
Hepatic/Renal Impairment:
- No dosage adjustment is required for moderate hepatic or renal impairment (creatinine clearance ≥10 mL/min).
- Patients with severe hepatic impairment (Child-Pugh score C) require close monitoring.
Children: Not applicable.
✔️ Interaction
- Co-administration with cimetidine or warfarin does not result in clinically significant interactions.
- Letrozole is metabolized by CYP3A4 and CYP2A6, but inhibitors of these enzymes have not shown significant interactions.
✔️ Contraindications
- Hypersensitivity to Letrozole or other aromatase inhibitors.
- Pregnancy, lactation, and premenopausal women.
- Severe hepatic dysfunction.
✔️ Overdose Effects of Letrozol 2.5
- Clinical Experience: Limited data on overdosage.
- Management: Supportive care, monitoring of vital signs, and emesis induction if alert. Dialysis may be considered due to low protein binding.
✔️ Pregnancy & Lactation
- Pregnancy: Category X. Studies in animals indicate teratogenic effects and fetal toxicity. Use in pregnant women is contraindicated.
- Lactation: It is unknown if letrozole is excreted in breast milk. Due to potential adverse effects on the infant, nursing is contraindicated during therapy.
✔️ Precautions & Warnings
- Hepatic Impairment: Exercise caution in patients with moderate hepatic dysfunction.
- Renal Impairment: No dose adjustment is needed for creatinine clearance ≥10 mL/min.
- Driving/Operating Machinery: Fatigue and dizziness may impair abilities; patients should be warned.
✔️ Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
